爆発的人気で全米視聴者数ナンバーワンの座に輝く話題作！
仲良しオタク男子四人組と個性的な女の子三人組が繰り広げる、大ヒットラブ・コメディ
テキサスからシェルドンの双子の妹ミッシーがやって来る。レナードたち３人はスレンダー美人のミッシーにメロメロ。その晩はシェルドンとレナードの部屋に泊まってもらう事にする。治験薬を試して女性と話せるようになったラージとハワードはミッシーを口説き始める。面白くないレナードは、ミッシーにふさわしい相手を捜すのは兄の責任だとシェルドンに入れ知恵するが…。
脚本 ： スティーブン・エンゲル、スティーブン・モラロ
監督 ： マーク・チェンドロフスキー
シェルドンTシャツ ： Damn 2.0 (Tron) T-Shirt, Shazam T-Shirt
ハワードバックル ： フラッシュ
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