シアトルのメディカルセンターへ移植用の心臓を受け取りに行くニーラとサム。その臓器移植の担当は偶然にもロスとキャロルだった。ロスたちは交通事故で死亡した孫の臓器提供に抵抗を見せる祖母の説得に当たる。その頃、シカゴのノースウェスタン病院では、カーターに腎臓移植の順番が来たことが告げられる。
ゲスト：ノア・ワイリー（カーター役）、ジョージ・クルーニー（ロス役）、ジュリアナ・マルグリーズ（キャロル役）、エリク・ラ・サル（ベントン役）、スーザン・サランドン『テルマ＆ルイーズ』、ルーニー・マーラー『ドラゴン・タトゥーの女』、アーネスト・ボーグナイン「超音速攻撃ヘリ エアーウルフ」、シリ・アップルビー「ロズウェル 星の恋人たち」、アリエル・ウィンター「モダン・ファミリー」
脚本：ジョン・ウェルズ
監督：ジョン・ウェルズ
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