現代のニューヨークを舞台に、シャーロック･ホームズがワトソン女史と難事件に挑む！
全米視聴率ナンバーワンを記録し話題の大ヒット犯罪捜査ミステリー
数学者フェリックス・ソトが射殺され、彼の部屋の外では路上強盗ベニーも撃たれていた。ベニーは一命を取り留めたが危篤状態。手がかりは見つからないが、ソトの部屋の壁にはブラックライトのみで見える数式がびっしり書き込まれていた。ホームズはそれが殺された理由と関係あるのではと見る。
ゲスト：リン・コリンズ『ジョン・カーター』、ジェレミー・ジョーダン「SMASH／スマッシュ」、グレン・フィッツジェラルド「ダーティ・セクシー・マネー」
脚本：ジェフリー・ポール・キング
監督：ジェリー・レヴィン
音楽："Guitar Between Us" by Chloe Kat / "Lightning Rod" by Erin Doherty / "Sea of Air"by Portugal. The Man
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