現代のニューヨークを舞台に、シャーロック・ホームズがワトソン女史と難事件に挑む!
全米視聴率ナンバーワンを記録し話題の大ヒット犯罪捜査ミステリー
ホームズらはサポートグループ仲間テスの妹の行方不明事件を引き受けることに。妹ペイジはミュージシャン志望の元依存症で、アパートに行ってみるとあるものが見つかる。そんな時、兄マイクロフトがロンドンからやってくる。経営するレストランのてこ入れに来たと言うが、ホームズはワトソン目当てではと疑うのだった。
ゲスト:リス・アイファンズ『ノッティングヒルの恋人』、キャンディス・ケイン「ダーティ・セクシー・マネー」
脚本:クレイグ・スウィーニー、スティーヴ・ゴットフリード
監督:シース・マン
音楽:"Never Be That Tough" by Simone White
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